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Epidemiology of healthcare-associated bloodstream infection in South African neonatal units | BMC Infectious Diseases

Epidemiology of healthcare-associated bloodstream infection in South African neonatal units | BMC Infectious Diseases
  • United Nations Inter-agency Group for Child Mortality Estimation (UN IGME). Levels & trends in Child Mortality: Report 2022, estimates developed by the United Nations Inter-agency Group for Child Mortality Estimation. New York: United Nations Children’s Fund; 2023.

    Google Scholar 

  • Levels & Trends in Child Mortality. Report 2020. United Nations Children’s Fund, The (UNICEF); 2020.

  • Liu L, Oza S, Hogan D, et al. Global, regional, and national causes of under-5 mortality in 2000-15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet. 2017;389(10082):1884.

    Google Scholar 

  • Sass L, Karlowicz MG. Healthcare-Associated Infections in the Neonate. Principles and Practice of Pediatric Infectious Diseases. 2018;560-566.e3. doi:10.1016/B978-0-323-40181-4.00094-3

  • Zingg W, Posfay-Barbe KM, Pittet D. Healthcare-associated infections in neonates. Curr Opin Infect Dis. 2008;21(3):228–34.

    Article 
    PubMed 

    Google Scholar 

  • Rangelova V. Risk factors for nosocomial infections in the neonatal Intensive Care Unit (NICU). Merit Res J Med Med Sci. 2021;9:319–24.

    Google Scholar 

  • Zaidi AKM, Huskins WC, Thaver D, Bhutta ZA, Abbas Z, Goldmann DA. Hospital-acquired neonatal infections in developing countries. Lancet Lond Engl. 2005;365(9465):1175–88.

    Article 

    Google Scholar 

  • Rothe C, Schlaich C, Thompson S. Healthcare-associated infections in sub-saharan Africa. J Hosp Infect. 2013;85(4):257–67.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Allegranzi B, Bagheri Nejad S, Combescure C, Graafmans W, Attar H, Donaldson L, et al. Burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysis. Lancet. 2011;377(9761):228–41.

    Article 
    PubMed 

    Google Scholar 

  • Fleischmann-Struzek C, Goldfarb DM, Schlattmann P, Schlapbach LJ, Reinhart K, Kissoon N. The global burden of paediatric and neonatal sepsis: a systematic review. Lancet Respir Med. 2018;6(3):223–30.

    Article 
    PubMed 

    Google Scholar 

  • Seale AC, Blencowe H, Manu AA, Nair H, Bahl R, Qazi SA, et al. Estimates of possible severe bacterial infection in neonates in sub-saharan Africa, south Asia, and Latin America for 2012: a systematic review and meta-analysis. Lancet Infect Dis. 2014;14(8):731–41.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Madhi SA, Pathirana J, Baillie V, Izu A, Bassat Q, Blau DM, et al. Unraveling specific causes of neonatal mortality using minimally invasive tissue sampling: an observational study. Clin Infect Dis off Publ Infect Dis Soc Am. 2019;69(Suppl 4):S351–60.

    Article 

    Google Scholar 

  • Dramowski A, Madide A, Bekker A. Neonatal nosocomial bloodstream infections at a referral hospital in a middle-income country: burden, pathogens, antimicrobial resistance and mortality. Paediatr Int Child Health. 2015;35(3):265–72.

    Article 
    PubMed 

    Google Scholar 

  • Reddy K, Bekker A, Whitelaw AC, Esterhuizen TM, Dramowski A. A retrospective analysis of pathogen profile, antimicrobial resistance and mortality in neonatal hospital-acquired bloodstream infections from 2009–2018 at Tygerberg Hospital, South Africa. PLoS ONE. 2021;16(1):e0245089.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Thomas R, Ondongo-Ezhet C, Motsoaledi N, Sharland M, Clements M, Velaphi S. Incidence, pathogens and antimicrobial resistance of blood and cerebrospinal fluid isolates from a tertiary neonatal unit in South Africa: A 10-year retrospective review. PLoS One. 2024;19(1):e0297371. 2019;14:e0214077.

  • Mashau R, Meiring S, Dramowski A, Magobo R, Quan V, von Gottberg A, et al. Culture-confirmed neonatal bloodstream infections and meningitis in South Africa, 2014–19: a cross-sectional study. Lancet Glob Health. 2022;10(8):e1170–1178.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bolton L, Bekker A, Govender N, van Schalkwyk C, Whitelaw A, Dramowski A. Neonatal sepsis: challenges in data access, harmonisation and analysis to inform empirical antibiotic recommendations in South African neonatal units. South Afr J Public Health. 2023;6(2):42–4.

    Article 

    Google Scholar 

  • Clinical and Laboratory Standards Institute (CLSI). (2017) Performance Standards for Antimicrobial Disk Susceptibility Tests. 12th Edition, Clinical and Laboratory Standards Institute, Wayne, PA.

  • Centers for disease. control and prevention NHSN Organism list; updated. 2021.

  • Tsai MH, Hsu JF, Chu SM, Lien R, Huang HR, Chiang MC, et al. Incidence, clinical characteristics and risk factors for adverse outcome in neonates with late-onset sepsis. Pediatr Infect Dis J. 2014;33(1):e7–13.

    Article 
    PubMed 

    Google Scholar 

  • Hebert C, Ridgway J, Vekhter B, Brown EC, Weber SG, Robicsek A. Demonstration of the weighted-incidence syndromic combination antibiogram: an empiric prescribing decision aid. Infect Control Hosp Epidemiol. 2012;33(4):381–8.

    Article 
    PubMed 

    Google Scholar 

  • Bielicki JA, Sharland M, Heath PT, et al. Evaluation of the coverage of 3 antibiotic regimens for neonatal sepsis in the hospital setting across Asian countries. JAMA Netw Open. 2020;3(2):e1921124.

    Article 
    PubMed 

    Google Scholar 

  • RStudio Team. RStudio: Integrated development environment for R. Last accessed: November 18, 2022.

  • R Core Team. R: A language environment for statistical computing. Last accessed: November 18, 2022.

  • Gezmu AM, Bulabula ANH, Dramowski A, Bekker A, Aucamp M, Souda S, et al. Laboratory-confirmed bloodstream infections in two large neonatal units in sub-saharan Africa. Int J Infect Dis. 2021;103:201–7.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Melariri H, Freercks R, van der Merwe E, Ham-Baloyi WT, Oyedele O, Murphy RA, Claasen C, Etusim PE, Achebe MO, Offiah S, Melariri PE. The burden of hospital-acquired infections (HAI) in sub-saharan Africa: a systematic review and meta-analysis. EClinicalMedicine. 2024;71:102571.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Okomo U, Akpalu ENK, Le Doare K, Roca A, Cousens S, Jarde A, et al. Aetiology of invasive bacterial infection and antimicrobial resistance in neonates in sub-saharan Africa: a systematic review and meta-analysis in line with the STROBE-NI reporting guidelines. Lancet Infect Dis. 2019;19(11):1219–34.

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Iroh Tam PY, Musicha P, Kawaza K, Cornick J, Denis B, Freyne B, et al. Emerging resistance to empiric antimicrobial regimens for Pediatric Bloodstream infections in Malawi (1998–2017). Clin Infect Dis. 2019;69(1):61–8.

    Article 
    PubMed 

    Google Scholar 

  • Cook A, Hsia Y, Russell N, Sharland M, Cheung K, Grimwood K, et al. Association of Empiric Antibiotic Regimen Discordance with 30-Day mortality in neonatal and Pediatric Bloodstream Infection-A global retrospective cohort study. Pediatr Infect Dis J. 2021;40(2):137–43.

    Article 
    PubMed 

    Google Scholar 

  • Dramowski A, Aucamp M, Beales E, Bekker A, Cotton MF, Fitzgerald FC, et al. Healthcare-Associated Infection Prevention Interventions for neonates in Resource-Limited settings. Front Pediatr. 2022;10:919403.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Russell N, Barday M, Okomo U, Dramowski A, Sharland M, Bekker A. Early-versus late-onset sepsis in neonates – time to shift the paradigm? Clin Microbiol Infect. 2024;30(1):38–43.

    Article 
    PubMed 

    Google Scholar 

  • Fuchs A, Bielicki J, Mathur S, Sharland M, Van Den Anker JN. Reviewing the WHO guidelines for antibiotic use for sepsis in neonates and children. Paediatr Int Child Health. 2018;38(sup1):3–15.

    Article 

    Google Scholar 

  • Jackson C, Hsia Y, Basmaci R, Bielicki J, Heath PT, Versporten A, et al. Global Divergence from World Health Organization Treatment Guidelines for Neonatal and Pediatric Sepsis. Pediatr Infect Dis J. 2019;38(11):1104–6.

    Article 
    PubMed 

    Google Scholar 

  • Abrahams I, Dramowski A, Moloto K, Lloyd L, Whitelaw A, Bekker A. Colistin use in a carbapenem-resistant enterobacterales outbreak at a South African neonatal unit. S Afr J Infect Dis. 2023;38(1):487.

    PubMed 
    PubMed Central 

    Google Scholar 

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